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ly 367385  (Bio-Techne corporation)


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    Bio-Techne corporation ly 367385
    Ly 367385, supplied by Bio-Techne corporation, used in various techniques. Bioz Stars score: 95/100, based on 260 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
    https://www.bioz.com/product/1237/LY+367385/custom%401237%4041935238
    Average 95 stars, based on 260 article reviews
    ly 367385 - by Bioz Stars, 2026-10
    95/100 stars

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    Chick Chorioallantoic Membrane Assay:

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    Image Search Results


    Comparison of GABA and mGluR modifying drugs on TA basal synaptic transmission (A) Example fEPSP traces recorded before and after drug incubation in WT (black) and Fmr1 -/y (red) mice. Drugs applied from left to right include: 20 μM baclofen (GABA B R agonist), 10 μM gabazine (GABA A R antagonist), 20 μM LY367385 (mGluR1α antagonist), 10 μM Fenobam (mGluR5 antagonist), and 10 μM s-DHPG (mGluR1/5 agonist). (B) Timecourse plots shown separately for each treatment condition and genotype. The duration of each drug application is shown above (black bar). (C) Mean fEPSP slope measured over the final 10 min of drug application for each of the drugs listed. (D) Paired-pulse ratio (PPR) before and after drug application. Data shown as mean ± SEM (B) or box-plots depicting 25%–75% range, maximum range (C,D) . WT and Fmr1 -/y sample sizes indicated in each bar); all with individual data points overlaid (open circles). Statistics shown from Mann Whitney tests (C) 2-way ANOVA (D) and Wilcoxon signed-rank tests (C) . Statistics shown as: ns-p > 0.05, * - p < 0.05; or ns p > 0.05, # - p < 0.05 (Wilcoxon signed-rank test).

    Journal: Frontiers in Pharmacology

    Article Title: Elevated somatostatin interneuron long-term potentiation minimally regulates temporoammonic plasticity in a mouse model of Fragile X Syndrome

    doi: 10.3389/fphar.2025.1640921

    Figure Lengend Snippet: Comparison of GABA and mGluR modifying drugs on TA basal synaptic transmission (A) Example fEPSP traces recorded before and after drug incubation in WT (black) and Fmr1 -/y (red) mice. Drugs applied from left to right include: 20 μM baclofen (GABA B R agonist), 10 μM gabazine (GABA A R antagonist), 20 μM LY367385 (mGluR1α antagonist), 10 μM Fenobam (mGluR5 antagonist), and 10 μM s-DHPG (mGluR1/5 agonist). (B) Timecourse plots shown separately for each treatment condition and genotype. The duration of each drug application is shown above (black bar). (C) Mean fEPSP slope measured over the final 10 min of drug application for each of the drugs listed. (D) Paired-pulse ratio (PPR) before and after drug application. Data shown as mean ± SEM (B) or box-plots depicting 25%–75% range, maximum range (C,D) . WT and Fmr1 -/y sample sizes indicated in each bar); all with individual data points overlaid (open circles). Statistics shown from Mann Whitney tests (C) 2-way ANOVA (D) and Wilcoxon signed-rank tests (C) . Statistics shown as: ns-p > 0.05, * - p < 0.05; or ns p > 0.05, # - p < 0.05 (Wilcoxon signed-rank test).

    Article Snippet: GABA B R agonist baclofen (Bacl; 20 μM), mGluR1α antagonist LY367385 (LY; 20 μM), mGluR5 antagonist Fenobam (Feno; 10 μM), and GABA A R antagonist gabazine (10 μM) were dissolved in dH 2 O or DMSO and sourced from HelloBio (HelloBio Ltd., United Kingdom) or Tocris (Bio-Techne Ltd., United Kingdom).

    Techniques: Comparison, Transmission Assay, Incubation, MANN-WHITNEY

    Summary of drug incubations on PTP and LTP magnitude post-HFS revealed no significant differences. (A) Post-HFS fEPSP slope (measured 0–1 min after stimulation) for PTP measured under control conditions and following application of baclofen (GABA B R agonist), gabazine (GABA A R antagonist), LY367385 (mGluR1α antagonist), Fenobam (mGluR5 antagonist), or s-DHPG (mGluR1/5 agonist); in wild-type (WT, black) and Fmr1 -/y (red) mice. (B) Data in the same form, but shown for LTP measured at 50–60 min post-HFS. All data shown as box-plots depicting 25%–75% range, maximum range; all with individual data points overlaid (open circles). Sample sizes (n = slices per group) are shown underneath. Statistics shown from 2-way ANOVA.

    Journal: Frontiers in Pharmacology

    Article Title: Elevated somatostatin interneuron long-term potentiation minimally regulates temporoammonic plasticity in a mouse model of Fragile X Syndrome

    doi: 10.3389/fphar.2025.1640921

    Figure Lengend Snippet: Summary of drug incubations on PTP and LTP magnitude post-HFS revealed no significant differences. (A) Post-HFS fEPSP slope (measured 0–1 min after stimulation) for PTP measured under control conditions and following application of baclofen (GABA B R agonist), gabazine (GABA A R antagonist), LY367385 (mGluR1α antagonist), Fenobam (mGluR5 antagonist), or s-DHPG (mGluR1/5 agonist); in wild-type (WT, black) and Fmr1 -/y (red) mice. (B) Data in the same form, but shown for LTP measured at 50–60 min post-HFS. All data shown as box-plots depicting 25%–75% range, maximum range; all with individual data points overlaid (open circles). Sample sizes (n = slices per group) are shown underneath. Statistics shown from 2-way ANOVA.

    Article Snippet: GABA B R agonist baclofen (Bacl; 20 μM), mGluR1α antagonist LY367385 (LY; 20 μM), mGluR5 antagonist Fenobam (Feno; 10 μM), and GABA A R antagonist gabazine (10 μM) were dissolved in dH 2 O or DMSO and sourced from HelloBio (HelloBio Ltd., United Kingdom) or Tocris (Bio-Techne Ltd., United Kingdom).

    Techniques: Control

    Group 1 mGluR modulation has no genotype effects on TA LTP in Fmr1 -/y mice. (A) Time-course of fEPSP slope following HFS at TA inputs in wild-type (WT, black) and Fmr1 -/y (red) mice, following 30 min bath application of the mGluR1α antagonist LY367385 (20 μM). Inset, example fEPSP traces from WT and Fmr1 -/y mice recorded before (black and red, respectively) and after HFS (grey and pink, respectively). PTP magnitude measured 1 min after HFS and LTP measured 50–60 min post-HFS, both relative to baseline fEPSP slope. Proportion of mice exhibiting successful LTP induction, defined as a 50–60 min post-HFS slope >10% above baseline. PPR measured before and after HFS, and CV 2 analysis pre- and post-HFS responses. WT: n = 6 slices; Fmr1 -/y : n = 12 slices. (B) The same data, but shown for TA LTP recordings performed after 30 min incubation with the mGluR5 antagonist Fenobam (10 μM). WT: n = 10 mice; Fmr1 -/y : n = 7 mice. (C) The same data, but shown for recordings performed after 30 min incubation with the mGluR1/5 agonist s-DHPG (10 μM). WT: n = 10 slices; Fmr1 -/y : n = 10 slices. Data is shown as mean ± SEM or box-plots depicting 25%–75% range, maximum range; all with individual data points overlaid (open circles). Statistics shown from Mann-Whitney tests, Chi-squared tests, 2-way ANOVA or Wilcoxon signed-rank tests; ns-p > 0.05 (Mann-Whitney test); or ns p > 0.05, # - p < 0.05 (Wilcoxon signed-rank tests).

    Journal: Frontiers in Pharmacology

    Article Title: Elevated somatostatin interneuron long-term potentiation minimally regulates temporoammonic plasticity in a mouse model of Fragile X Syndrome

    doi: 10.3389/fphar.2025.1640921

    Figure Lengend Snippet: Group 1 mGluR modulation has no genotype effects on TA LTP in Fmr1 -/y mice. (A) Time-course of fEPSP slope following HFS at TA inputs in wild-type (WT, black) and Fmr1 -/y (red) mice, following 30 min bath application of the mGluR1α antagonist LY367385 (20 μM). Inset, example fEPSP traces from WT and Fmr1 -/y mice recorded before (black and red, respectively) and after HFS (grey and pink, respectively). PTP magnitude measured 1 min after HFS and LTP measured 50–60 min post-HFS, both relative to baseline fEPSP slope. Proportion of mice exhibiting successful LTP induction, defined as a 50–60 min post-HFS slope >10% above baseline. PPR measured before and after HFS, and CV 2 analysis pre- and post-HFS responses. WT: n = 6 slices; Fmr1 -/y : n = 12 slices. (B) The same data, but shown for TA LTP recordings performed after 30 min incubation with the mGluR5 antagonist Fenobam (10 μM). WT: n = 10 mice; Fmr1 -/y : n = 7 mice. (C) The same data, but shown for recordings performed after 30 min incubation with the mGluR1/5 agonist s-DHPG (10 μM). WT: n = 10 slices; Fmr1 -/y : n = 10 slices. Data is shown as mean ± SEM or box-plots depicting 25%–75% range, maximum range; all with individual data points overlaid (open circles). Statistics shown from Mann-Whitney tests, Chi-squared tests, 2-way ANOVA or Wilcoxon signed-rank tests; ns-p > 0.05 (Mann-Whitney test); or ns p > 0.05, # - p < 0.05 (Wilcoxon signed-rank tests).

    Article Snippet: GABA B R agonist baclofen (Bacl; 20 μM), mGluR1α antagonist LY367385 (LY; 20 μM), mGluR5 antagonist Fenobam (Feno; 10 μM), and GABA A R antagonist gabazine (10 μM) were dissolved in dH 2 O or DMSO and sourced from HelloBio (HelloBio Ltd., United Kingdom) or Tocris (Bio-Techne Ltd., United Kingdom).

    Techniques: Incubation, MANN-WHITNEY